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Enkephalin

Meaning

Enkephalins are endogenous opioid peptides naturally produced in the brain and adrenal glands that function as neurotransmitters and neuromodulators, playing a crucial role in the body’s intrinsic pain-relief system. These pentapeptides bind to opioid receptors, particularly the delta and mu receptors, to inhibit the transmission of pain signals and influence mood and behavior. They are essential components of the endogenous opioid system, providing a powerful, natural mechanism for modulating pain perception and emotional response. Clinically, understanding enkephalin pathways informs the treatment of chronic pain and emotional dysregulation.