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Energy Substrate Replenishment

Meaning

Energy Substrate Replenishment is the critical physiological process of restoring the body’s primary sources of metabolic fuel, which are predominantly the muscle and liver glycogen stores, and to a lesser but still significant extent, the intramuscular triglycerides, following periods of intense physical exertion or sustained metabolic demand. This is an absolutely critical, non-negotiable recovery phase that is essential for fully restoring metabolic capacity and preventing the onset of chronic fatigue. The efficiency and completeness of this replenishment process are heavily and directly influenced by specific hormonal signaling, most importantly insulin sensitivity.