The biological process by which excess caloric energy from macronutrients is converted into stable, compact forms for later use by the body, primarily as glycogen in the liver and muscle, and as triglycerides in adipose tissue. This fundamental physiological function is tightly regulated by hormones like insulin and glucagon, ensuring metabolic stability and survival during periods of fasting or high energy demand. Dysregulation of this system is central to metabolic syndrome and weight management challenges.
Origin
This is a core concept in biochemistry and human physiology, where “energy” relates to the capacity to do work, and “storage” refers to the biological sequestration of this capacity. The term reflects the evolutionary imperative for organisms to buffer against inconsistent food availability. In the context of wellness, it addresses the modern challenge of chronic energy surplus and its consequences.
Mechanism
The mechanism is hormonally driven; after a meal, insulin facilitates the uptake of glucose into cells for glycogen synthesis (glycogenesis) and promotes the conversion of excess glucose and fatty acids into triglycerides for deposition in adipocytes (lipogenesis). Conversely, during fasting, glucagon and catecholamines trigger the breakdown of stored glycogen (glycogenolysis) and triglycerides (lipolysis) to release energy substrates back into the circulation.
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