Skip to main content

Energy Mobilization Cascade

Meaning

The Energy Mobilization Cascade describes the sequential hormonal and enzymatic signaling events triggered by perceived energy deficit, leading to the release of stored substrates—glycogenolysis, lipolysis, and subsequent gluconeogenesis—to maintain systemic glucose homeostasis. This cascade is centrally regulated by counter-regulatory hormones like glucagon, epinephrine, and cortisol, working in opposition to insulin’s storage signal. Effective management of this cascade is vital for sustaining physical and cognitive function during periods of fasting or high demand. It is the body’s prioritized system for accessing fuel reserves.