What is the Origin of Energy Homeostasis Failure?

The term is rooted in the physiological concept of "homeostasis," derived from the Greek homoios (similar) and stasis (standing still), referring to the maintenance of internal stability. "Energy homeostasis" specifically applies this principle to caloric balance, and its "failure" denotes a transition from controlled regulation to a dysregulated, often pathological, state.

What is the Mechanism of Energy Homeostasis Failure?

This failure typically involves central resistance to key satiety hormones, such as leptin and insulin, within the arcuate nucleus of the hypothalamus. Peripheral factors, including altered gut microbiota and chronic low-grade inflammation, further impair the accurate signaling of energy status to the brain. The result is a persistent drive for energy intake (orexigenic signaling) that overrides the body's natural satiety mechanisms, leading to progressive weight dysregulation and metabolic syndrome.

Energy Homeostasis Failure ∞ Area

Energy Homeostasis Failure

Meaning

A pathological state characterized by the body’s inability to maintain a stable balance between energy intake (food consumption) and energy expenditure (metabolism and activity), resulting in chronic positive or negative energy balance. Clinically, this failure is often manifested as obesity or severe malnutrition, representing a breakdown in the complex neuroendocrine feedback loops that regulate body weight and fat mass. It signifies a profound disruption in metabolic control.