The state of achieving highly efficient and flexible regulation of the body’s energy production, utilization, and storage across diverse metabolic demands and environmental conditions. This mastery is characterized by superior mitochondrial function, optimized substrate partitioning between fat and glucose, and stable blood sugar control. It signifies a robust metabolic phenotype that supports sustained high performance and minimizes the accumulation of metabolic waste products.
Origin
This term is a construct within the longevity and performance science domains, evolving from the core physiological concepts of bioenergetics and metabolic flexibility. ‘Economy’ refers to the efficiency of resource use, and ‘mastery’ denotes the optimal, adaptive control over these fundamental metabolic processes, moving beyond simple caloric balance.
Mechanism
At the cellular level, mastery is driven by the efficient coupling of the electron transport chain in the mitochondria, maximizing ATP yield with minimal reactive oxygen species generation. Hormones like insulin, glucagon, and thyroid hormones work in concert to direct the body to switch seamlessly between utilizing fat for fuel during rest or low-intensity activity and glucose during high-intensity exertion. This adaptive metabolic switching is the hallmark of a high-functioning energy economy.
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