The physiological and clinical strategy centered on optimizing the synthesis, distribution, and efficient utilization of Adenosine Triphosphate (ATP), the primary energy molecule of the cell. Effective management ensures that all tissues, especially the brain and muscle, have a stable and responsive supply of high-grade energy. This concept encompasses the balance between energy production (catabolism) and energy storage (anabolism).
Origin
This term is a conceptual bridge between cellular biochemistry, where ATP is literally the energy ‘currency,’ and clinical practice, where managing its production is key to health and performance. The concept originates from the study of mitochondrial bioenergetics.
Mechanism
The core mechanism is mitochondrial efficiency, specifically the rate of oxidative phosphorylation within the inner mitochondrial membrane. Hormones like thyroid hormone and insulin play direct roles in regulating metabolic rate and substrate utilization, impacting ATP generation. Clinical interventions focus on providing the necessary cofactors and optimizing substrate availability, such as fatty acids and glucose, to fuel this process.
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