The sustained, high-level capacity for cognitive function, encompassing executive processes, memory, attention, and processing speed, that is maintained across the lifespan and resilient to age-related neurodegeneration. This state is achieved through the active protection and optimization of neuronal health, cerebral blood flow, and neuroendocrine balance. It is a clinical goal focused on maximizing cognitive reserve and mental acuity into later years.
Origin
This is a descriptive term synthesizing the neurological concept of “intellect” with the longevity focus on “enduring” or sustained function, often used in the context of neuro-optimization and anti-aging medicine. It emphasizes the quality and resilience of cognitive capacity over time.
Mechanism
Enduring Intellect is fundamentally supported by robust neuroplasticity and synaptic integrity, processes that are significantly modulated by hormones and growth factors. Adequate levels of neuroprotective hormones, such as optimized estrogen and testosterone, along with sustained Brain-Derived Neurotrophic Factor (BDNF) signaling, promote the formation of new neural connections and protect existing neurons from oxidative stress and excitotoxicity. Maintaining cerebral vascular health is also critical for ensuring optimal nutrient and oxygen delivery.
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