Skip to main content

Endotoxin Translocation Mitigation

Meaning

Endotoxin translocation mitigation is the clinical and physiological objective of reducing the pathological passage of lipopolysaccharide (LPS), a pro-inflammatory component of Gram-negative bacterial cell walls, from the intestinal lumen into the systemic circulation. Excessive translocation, often referred to as metabolic endotoxemia, is a significant, chronic driver of low-grade systemic inflammation, which is intrinsically linked to the development of insulin resistance and widespread hormonal dysfunction. Mitigation strategies are therefore specifically designed to reinforce the integrity and barrier function of the intestinal epithelial lining.