What is the Origin of Endotoxin Leakage?

This term is rooted in immunology and microbiology, specifically describing the translocation of bacterial components, often termed "metabolic endotoxemia," which correlates strongly with compromised gut barrier function. It is a key concept in understanding systemic aging processes.

What is the Mechanism of Endotoxin Leakage?

When the tight junctions between colonocytes become pathologically loosened, often due to dysbiosis or nutrient deficiency, LPS molecules cross the barrier. Once systemic, these endotoxins bind to immune receptors like TLR4, initiating an inflammatory cascade that negatively impacts insulin sensitivity and overall endocrine signaling fidelity throughout the body.

Endotoxin Leakage ∞ Area

Endotoxin Leakage

Meaning

Endotoxin Leakage describes the pathological process where bacterial lipopolysaccharides (LPS), potent inflammatory mediators from Gram-negative bacteria, translocate from the intestinal lumen across a compromised intestinal epithelial barrier into the systemic circulation. This drives chronic low-grade inflammation.