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Endotoxin Adjuvant

Meaning

An Endotoxin Adjuvant refers to the use of bacterial endotoxin, specifically the lipopolysaccharide (LPS) component of the outer membrane of Gram-negative bacteria, to enhance the body’s immune response to a co-administered antigen. In a clinical or research setting, a purified and often detoxified derivative of LPS is employed as an adjuvant, a substance that non-specifically boosts the immune system’s readiness. This potent immune-stimulatory capacity is leveraged to improve the efficacy of vaccines or to study innate immune pathways. The strong inflammatory nature of the molecule requires careful preparation to minimize systemic toxicity.