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Endotoxin

Meaning

An Endotoxin is a lipopolysaccharide component found in the outer membrane of Gram-negative bacteria, which is released upon bacterial cell lysis or death. In human physiology, the presence of circulating endotoxin, often referred to as lipopolysaccharide or LPS, triggers a robust innate immune response. Elevated systemic levels of this molecule are clinically associated with a state of chronic, low-grade inflammation, metabolic dysfunction, and compromised gut barrier integrity. Understanding endotoxin exposure is crucial when evaluating the root causes of systemic inflammation in hormonal health.