What is the Origin of Endothelial Function Integrity?

This concept is central to cardiovascular physiology and has gained significant attention in longevity and hormonal health, recognizing the endothelium as a critical endocrine organ itself. The term emphasizes the importance of the vascular system as the delivery network for all endocrine signals. Its clinical measurement provides a direct, non-invasive assessment of systemic vascular health.

What is the Mechanism of Endothelial Function Integrity?

Optimal integrity is maintained by a balanced release of vasoactive substances, with nitric oxide (NO) being the key player, synthesized by endothelial nitric oxide synthase (eNOS). Hormones like estrogen and testosterone exert protective effects by promoting eNOS activity and reducing oxidative stress within the vascular wall. Impaired function occurs when oxidative stress and chronic inflammation deplete NO bioavailability, leading to vasoconstriction and reduced blood flow.

Endothelial Function Integrity ∞ Area

Endothelial Function Integrity

Meaning

Endothelial Function Integrity refers to the optimal physiological state of the endothelium, the single layer of cells lining the interior surface of all blood vessels, which is critical for regulating vascular tone, blood flow, and inflammatory response. High integrity signifies a healthy ability to produce and respond to vasodilators, primarily nitric oxide, ensuring efficient nutrient and hormone delivery throughout the body. Dysfunction, often a precursor to cardiovascular disease, is characterized by impaired vasodilation and increased vascular inflammation. Maintaining this integrity is paramount for hormonal transport and overall systemic health.