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Endothelial Damage

Meaning

Endothelial Damage refers to the pathological injury, functional impairment, or structural dysfunction of the endothelium, which is the delicate, single layer of specialized cells lining the interior surface of all blood vessels, including arteries, veins, and capillaries. This damage is consistently recognized as a critical early event in the pathogenesis of numerous cardiovascular and complex metabolic diseases, fundamentally impairing the vessel’s vital ability to regulate its tone, control local inflammation, and manage coagulation processes. Systemic hormonal imbalances, such as chronic insulin resistance or progressive estrogen deficiency, are consistently identified as significant and measurable contributors to this damage, highlighting the close, inseparable link between endocrinology and vascular health. Restoring robust endothelial function is a key therapeutic target for promoting longevity and reducing overall cardiovascular risk.