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Endosomal Trafficking Regulation

Meaning

Endosomal Trafficking Regulation is the controlled process governing the movement, sorting, and fate of internalized molecules, including activated hormone-receptor complexes, within the endosomal system of a cell. This regulation determines whether a receptor is recycled back to the cell surface for further signaling, degraded in the lysosome to terminate the signal, or routed to another cellular compartment. Precise control over endosomal trafficking is essential for maintaining the appropriate level of cellular sensitivity to external signals, such as growth factors and peptide hormones. Dysfunction in this process can lead to aberrant signaling, contributing to conditions like hormone resistance or uncontrolled cell growth.