What is the Origin of Endometrial Receptivity Analysis?

The test originated from the clinical observation that even high-quality embryos often fail to implant due to a non-receptive endometrium, indicating a mismatch between the embryo and the uterine lining. ERA was developed as a molecular tool to move beyond traditional, less precise histological dating of the endometrium. This innovation marks a significant step toward personalized medicine in the field of assisted reproductive technology (ART).

What is the Mechanism of Endometrial Receptivity Analysis?

The mechanism involves obtaining a small endometrial biopsy on a pre-determined day of a simulated or natural cycle. Messenger RNA is then extracted from the tissue sample and analyzed for the expression levels of key genes that correlate with endometrial receptivity. A proprietary algorithm compares the patient's gene expression pattern to a validated receptive signature. This comparison allows the clinician to identify if the endometrium is Receptive, Pre-receptive, or Post-receptive, enabling the subsequent embryo transfer to be timed optimally.

Endometrial Receptivity Analysis ∞ Area

Endometrial Receptivity Analysis

Meaning

Endometrial Receptivity Analysis (ERA) is a specialized diagnostic test in reproductive endocrinology that assesses the molecular readiness of the uterine lining, the endometrium, to accept an implanting embryo. This analysis determines the personalized Window of Implantation (WOI) by evaluating the expression profile of a panel of specific genes within the endometrial tissue. The test is clinically valuable for guiding the precise timing of frozen embryo transfer, especially in cases of recurrent implantation failure.