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Endometrial Protection Strategy

Meaning

Endometrial Protection Strategy is a critical clinical protocol for women with an intact uterus who are undergoing estrogen replacement therapy, designed to prevent the risk of estrogen-driven, unopposed proliferation of the endometrium, the uterine lining. This strategy necessitates the co-administration of progesterone or a progestin for a specified duration each cycle to induce a secretory change and shedding of the lining. It is a fundamental safety measure in hormonal therapy, ensuring the proliferative stimulus of estrogen is counteracted to mitigate the risk of endometrial hyperplasia and subsequent carcinoma.