What is the Origin of Endometrial Assessment?

This clinical practice is rooted in the understanding that the endometrium is a primary target tissue for the cyclical effects of ovarian steroid hormones, estrogen and progesterone. The development of non-invasive tools like transvaginal ultrasound, and more invasive techniques like biopsy, established a standard protocol for monitoring this hormone-responsive tissue.

What is the Mechanism of Endometrial Assessment?

The assessment typically begins with a transvaginal ultrasound to measure endometrial thickness, which is highly correlated with estrogen exposure. Further investigation may involve an endometrial biopsy or hysteroscopy to obtain tissue for histological and molecular analysis. This analysis can detect cellular abnormalities like estrogen-driven hyperplasia or identify molecular markers, such as BCL6 protein overexpression, which indicate progesterone resistance and implantation failure.

Endometrial Assessment ∞ Area

Endometrial Assessment

Meaning

Endometrial assessment is a crucial clinical procedure used in gynecology and reproductive endocrinology to evaluate the structure, thickness, morphology, and cellular health of the endometrium, the inner lining of the uterus. This evaluation is essential for diagnosing the underlying causes of abnormal uterine bleeding, monitoring the safety of hormone therapy, and assessing endometrial receptivity in fertility workups. It is a non-negotiable step in managing female hormonal health.