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Endogenous Testosterone Stimulation

Meaning

Endogenous testosterone stimulation is a clinical and physiological strategy aimed at increasing the body’s natural, internal production of testosterone by targeting the upstream regulatory components of the hypothalamic-pituitary-gonadal (HPG) axis. This approach contrasts sharply with exogenous testosterone replacement therapy, which introduces external hormone and often suppresses the body’s native production. The goal is to revitalize the testes’ function to synthesize and secrete testosterone, thereby restoring optimal physiological levels while preserving fertility and maintaining testicular volume.