Therapeutic interventions designed to restore the natural, self-generated signaling cascades within the body, particularly those involving receptor activation by native ligands. This correction aims to re-sensitize cellular communication pathways disrupted by aging or physiological stress. It focuses on optimizing the body’s intrinsic communication network.
Origin
This concept derives from cellular pharmacology, emphasizing the distinction between exogenous agents and the body’s own signaling molecules. In wellness science, it addresses issues where receptor function is impaired despite adequate ligand presence. It highlights the necessity of functional cellular reception.
Mechanism
Correction involves strategies that enhance receptor expression, improve ligand-receptor binding affinity, or optimize downstream signal transduction components. For instance, supporting appropriate nutrient status can enhance the cellular machinery required for intracellular signaling cascades. This process ultimately normalizes the cellular response profile to endogenous cues.
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