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Endogenous Signal Calibration

Meaning

Endogenous Signal Calibration refers to the body’s intrinsic and continuous process of precisely tuning the sensitivity of cellular receptors and feedback loops to its own internally produced hormones, peptides, and neurotransmitters. This mechanism ensures that the physiological response to a given chemical signal remains appropriate and proportional to the body’s current metabolic and environmental context. Clinically, impaired calibration is a hallmark of many endocrine disorders, where tissues either become resistant or hypersensitive to a circulating messenger, leading to systemic dysfunction despite normal hormone levels. Optimal calibration is vital for maintaining robust homeostatic and allostatic balance.