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Endogenous Secretion Pulsing

Meaning

Endogenous Secretion Pulsing refers to the natural, intermittent, and rhythmic release of hormones from endocrine glands into the bloodstream, occurring in distinct, high-frequency bursts rather than a continuous, steady stream. This pulsatile pattern is a fundamental characteristic of nearly all neuroendocrine axes, including the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes. Maintaining the correct amplitude and frequency of these pulses is physiologically crucial, as target tissues often require this dynamic pattern for optimal receptor sensitivity and cellular signaling integrity. Disruption of this rhythmic release, which is common with aging or stress, can lead to functional hormonal deficiency.