Endogenous rhythms are the intrinsic, self-sustaining biological cycles, most notably the circadian rhythm, that regulate nearly all physiological processes independent of immediate external cues, though they are typically synchronized by them. These rhythms dictate the pulsatile release patterns of critical hormones like cortisol, growth hormone, and melatonin, thereby governing the timing of metabolic activity across the 24-hour cycle. Understanding these inherent timings is central to optimizing hormonal health.
Origin
The term combines Greek roots: endon (within) and genos (origin), signifying rhythms generated internally, coupled with the general biological concept of cyclical periodicity observed in living systems. This framework has deep roots in the field of chronobiology research.
Mechanism
The primary mechanism involves the master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which utilizes complex molecular feedback loops involving core clock genes like CLOCK and BMAL1 to generate precise timing signals. These signals are then transmitted throughout the organism, coordinating the daily ebb and flow of hormone secretion and target tissue responsiveness.
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