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Endogenous Release Pattern Resumption

Meaning

Endogenous Release Pattern Resumption refers to the clinical goal of restoring the body’s native, naturally rhythmic, and pulsatile secretion profile of a specific hormone, especially after it has been suppressed or disrupted by external factors or pathological states. This is a key objective in hormonal therapy, moving beyond simply achieving target concentration levels to re-establishing the correct timing and amplitude of hormone pulses. Successful resumption is essential for maximizing the hormone’s physiological effectiveness and preventing receptor desensitization, which often occurs with non-pulsatile or continuous administration. It is the hallmark of true endocrine system recovery.