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Endogenous Release Amplification

Meaning

Endogenous Release Amplification is the physiological process of enhancing the body’s own natural production and secretion rate of a specific hormone or signaling molecule. This therapeutic goal is distinct from exogenous replacement, aiming instead to stimulate the native endocrine gland to increase its output, often through upstream signaling modulation. Clinically, this strategy is favored to restore hormonal balance by promoting the body’s inherent capacity for self-regulation and maintaining the pulsatile, nuanced release patterns characteristic of healthy endocrine function.