What is the Origin of Endogenous Pulse?

This term is central to chronobiology and neuroendocrinology, where the pulsatile release of hypothalamic-pituitary hormones was first observed and recognized as crucial for preventing receptor downregulation. The etymology refers to the signal being generated endogenously, or from within the body's own regulatory centers.

What is the Mechanism of Endogenous Pulse?

The Endogenous Pulse mechanism involves the cyclical activation of neurosecretory cells in the hypothalamus, which release releasing hormones in discrete bursts that subsequently stimulate the pituitary gland. This intermittent stimulation prevents the target cell receptors from becoming saturated and desensitized, ensuring that the downstream endocrine glands remain highly responsive to the hormonal signals, thereby preserving the fidelity of the endocrine axis.

Endogenous Pulse

Meaning

The naturally occurring, rhythmic, and often pulsatile secretion pattern of specific hormones, most notably pituitary hormones like Luteinizing Hormone (LH) and Growth Hormone (GH), which is essential for maintaining receptor sensitivity and optimal physiological function. This inherent rhythmicity is a key characteristic of a healthy endocrine system.