A set of quantifiable biochemical markers and physiological parameters used to assess the body’s inherent capacity and rate of synthesis for specific hormones, proteins, or other vital compounds. These metrics differentiate between the body’s own output and any contributions from exogenous supplementation, providing a true measure of glandular function. This objective data is crucial for titrating replacement therapies and evaluating long-term glandular health.
Origin
This term is derived from clinical biochemistry and pharmacology, where “endogenous” means originating from within an organism, and “production metrics” are the quantifiable standards of output. The need for these metrics arose with the advent of hormone replacement therapies to ensure that treatment was optimizing, not replacing, natural physiological function where possible.
Mechanism
Measurement techniques often involve dynamic testing, such as stimulation or suppression tests, to challenge a gland and measure its maximum output capacity. Specific blood or urine markers, including precursor hormones or unique metabolites not present in the exogenous compound, are quantified. For example, C-peptide levels are used to assess endogenous insulin production in diabetic patients.
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