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Endogenous Peptide Sensitivity

Meaning

Endogenous Peptide Sensitivity describes the precise degree of responsiveness exhibited by cellular receptors and signaling pathways to the body’s own naturally produced peptide hormones and signaling molecules. This sensitivity is a critical determinant of hormonal efficacy, dictating how strongly a given concentration of a peptide, such as insulin, ghrelin, or leptin, will successfully elicit a physiological response. High sensitivity is synonymous with robust endocrine health and efficient systemic communication, whereas significantly reduced sensitivity is a clinical hallmark of many metabolic and age-related dysfunctions. Maintaining optimal sensitivity is absolutely key to sustained metabolic and overall hormonal balance.