What is the Origin of Endogenous Peptide Release?

This concept is rooted in the field of molecular endocrinology, which shifted focus from only steroid and monoamine hormones to the vast, complex family of regulatory peptides discovered in the latter half of the 20th century. The term emphasizes the body's inherent capacity to produce these vital regulators, contrasting with exogenous administration.

What is the Mechanism of Endogenous Peptide Release?

Peptide release is typically triggered by specific neural or humoral stimuli and occurs via the regulated exocytosis of secretory vesicles from specialized endocrine or neuroendocrine cells. Once released, these peptides bind to specific cell-surface receptors, initiating a cascade of intracellular signaling events, such as the cAMP pathway, to elicit a rapid and potent biological response. The precise timing and quantity of this release are essential for maintaining systemic communication and metabolic rhythm.

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Endogenous Peptide Release

Meaning

Endogenous peptide release refers to the natural, intrinsic secretion of short-chain amino acid molecules, known as peptides, that act as signaling molecules within the human body. These peptides perform diverse regulatory roles, functioning as hormones, neurotransmitters, or local growth factors to modulate complex physiological processes. The clinical goal is often to support or optimize the pulsatile and rhythmic release of these native signaling agents, such as growth hormone-releasing peptides or immune-modulating thymic peptides.