Clinical interventions designed to augment the body’s inherent capacity to synthesize and release its own vital signaling molecules, such as growth hormone, sex steroids, or specific neurotransmitters. This contrasts with exogenous replacement therapy by focusing on optimizing internal production machinery. We seek to reignite the body’s natural physiological engine.
Origin
This term arises from the field of restorative endocrinology, emphasizing the physiological potential remaining even in states of suboptimal function. It acknowledges the inherent feedback mechanisms governing hormone production. The origin lies in understanding the upstream regulators like the hypothalamus and pituitary.
Mechanism
Stimulation occurs by addressing limiting factors that suppress natural output, such as correcting nutrient deficiencies that impair synthesis or modulating negative feedback loops that inhibit release. For example, optimizing the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) can effectively stimulate downstream testicular or ovarian output. The process relies on restoring the sensitivity and responsiveness of the HPG or HPA axes to endogenous cues.
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