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Endogenous Opioid System

Meaning

The Endogenous Opioid System (EOS) is a vital neuromodulatory network comprised of opioid peptides and their specific receptors distributed throughout the central and peripheral nervous systems. This intrinsic system plays a crucial role in regulating a spectrum of physiological processes, including pain relief, stress response, emotional control, and reward-seeking behavior. The peptides, such as endorphins, enkephalins, and dynorphins, function as natural internal ligands for the opioid receptors. Optimal function of the EOS is deeply intertwined with overall mental and physical wellness, impacting resilience and quality of life.