What is the Origin of Endogenous Neuroprotection?

The term combines 'Endogenous' (originating or produced within an organism) and 'Neuroprotection' (protection of nervous tissue). The recognition of the brain's self-preserving capacity grew from research into how the brain responds to acute injury and chronic neurodegenerative diseases. This research identified specific molecules and pathways that actively resist damage.

What is the Mechanism of Endogenous Neuroprotection?

This defense is mediated by various factors, including the production of neurotrophins like BDNF, the anti-inflammatory actions of glial cells, and the direct antioxidant effects of endogenous molecules like glutathione. Certain neurosteroids, such as allopregnanolone and DHEA, directly stabilize neuronal membranes and modulate receptor activity to prevent excessive calcium influx, a key mechanism of cell death. The system's effectiveness is intrinsically linked to systemic metabolic and hormonal health.

Endogenous Neuroprotection ∞ Area

Endogenous Neuroprotection

Meaning

The collection of inherent, self-generated biological mechanisms within the central nervous system that shield neurons from injury, oxidative stress, excitotoxicity, and programmed cell death. This intrinsic defense system is a continuous process essential for maintaining neural integrity and function throughout the lifespan. Hormonal signaling and genetic factors are primary regulators of this crucial protective capacity.