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Endogenous Hypercortisolism

Meaning

Endogenous Hypercortisolism describes a clinical state characterized by persistently and pathologically elevated levels of cortisol produced autonomously by the body itself, as opposed to elevation from external medication. This condition is primarily known as Cushing’s syndrome and leads to a distinctive constellation of metabolic, physical, and psychological symptoms due to chronic overexposure to glucocorticoids. Clinical diagnosis requires rigorous endocrine testing to confirm the autonomous, unregulated overproduction of this critical stress hormone.