The total quantity of a specific hormone that is naturally synthesized and secreted by the body’s endocrine glands over a defined period, reflecting the functional capacity of the respective gland. This yield is distinct from exogenous hormone administration and serves as a crucial biomarker for assessing baseline endocrine health. It encompasses the entire biosynthetic pathway, from precursor availability to final secretion.
Origin
The term combines “endogenous,” meaning originating from within an organism, with “hormone” and “yield,” a concept borrowed from chemistry and production, signifying the total output. In clinical practice, measuring this yield helps differentiate primary glandular failure from central regulatory issues within the hypothalamic-pituitary axis.
Mechanism
The process is governed by a tightly controlled neuroendocrine feedback loop, where the hypothalamus and pituitary gland release tropic hormones that stimulate the target endocrine gland, such as the thyroid or gonads, to produce and secrete the final hormone. Precursor availability, enzymatic activity, and the integrity of the glandular tissue are all critical factors that determine the ultimate quantity of the endogenous hormone yield.
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