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Endogenous Hormone Variance

Meaning

Endogenous hormone variance describes the natural, often predictable, fluctuations in the concentrations of hormones synthesized within the body, independent of external pharmaceutical intervention. This variance encompasses rhythmic changes, such as circadian, ultradian, and infradian cycles, as well as random, pulsatile releases. Understanding and mapping an individual’s specific variance profile is paramount in clinical endocrinology, as it defines the physiological baseline and informs the timing of diagnostic testing. Significant deviation from an established, healthy variance pattern often signals underlying dysfunction in the neuro-endocrine axes.