Endogenous Hormone Secretion defines the process by which the body’s own endocrine glands produce and release hormones directly into the bloodstream or interstitial fluid without external administration. This describes the native, self-regulated production of signaling molecules like insulin, testosterone, or estrogen necessary for physiological maintenance. Evaluating the level and pattern of endogenous secretion is fundamental to diagnosing hormonal insufficiency or excess states. We aim to support and restore robust native production whenever possible.
Origin
The term is built from ‘Endogenous,’ meaning originating from within the organism, contrasted with exogenous sources. ‘Hormone’ comes from the Greek hormaein, to set in motion, and ‘Secretion’ describes the process of releasing a substance from a cell or gland. It directly references the primary function of the endocrine system.
Mechanism
This secretion is typically controlled via negative and positive feedback loops involving the HPA, HPG, or HPT axes, often initiated by hypothalamic releasing factors or pituitary tropic hormones. For example, pulsatile GnRH release dictates the rhythmic secretion of LH and FSH from the pituitary. Maintaining the sensitivity of the feedback receptors is paramount to ensuring appropriate secretory responses to physiological demands.
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