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Endogenous Hormone Replacement

Meaning

Endogenous Hormone Replacement is a clinical concept describing therapeutic strategies that stimulate and support the body’s innate endocrine glands to increase their own natural production of hormones. This approach contrasts sharply with conventional exogenous hormone replacement, which introduces hormones from an external source. The goal is to revitalize the Hypothalamic-Pituitary-Gonadal (HPG) and Hypothalamic-Pituitary-Adrenal (HPA) axes to achieve physiological hormone levels naturally. It represents a paradigm shift toward regenerative endocrinology.