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Endogenous Hormone Pulsation

Meaning

This refers to the natural, rhythmic, and intermittent bursts of hormone secretion that characterize the release of many key regulatory hormones, such as Gonadotropin-Releasing Hormone (GnRH) and Growth Hormone (GH), from the endocrine glands. This non-continuous, pulsatile release pattern is biologically essential for maintaining receptor sensitivity and preventing the desensitization that occurs with constant, non-physiologic exposure. Clinical strategies often aim to mimic this natural pulsation to optimize therapeutic efficacy and preserve endocrine feedback integrity. The frequency and amplitude of these pulses convey crucial biological information.