What is the Origin of Endogenous Hormone Assays?

The origin lies in the development of radioimmunoassay (RIA) and, subsequently, more advanced techniques like liquid chromatography-tandem mass spectrometry (LC-MS/MS) within clinical chemistry and endocrinology. The precision of these assays is paramount for accurate clinical interpretation. The term specifies the measurement of naturally synthesized compounds, differentiating them from synthetic analogs.

What is the Mechanism of Endogenous Hormone Assays?

These assays employ highly specific antibodies or separation techniques to isolate and quantify the native hormone molecules present in blood, saliva, or urine. The measured concentrations reflect the balance between hormone synthesis, secretion, and metabolic clearance rates. Accurate assessment of endogenous levels is crucial for determining baseline function and for precisely tailoring any necessary bioidentical hormone replacement or modulatory therapy.

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Endogenous Hormone Assays

Meaning

Endogenous Hormone Assays are specialized laboratory tests designed to measure the circulating concentrations of hormones naturally produced within the body. These assays provide quantitative data on the body’s intrinsic endocrine output, distinguishing it from hormone levels derived from exogenous, or externally administered, sources. They are essential for diagnosing primary endocrine disorders and monitoring the integrity of the hypothalamic-pituitary-gonadal (HPG) and adrenal axes.