What is the Meaning of Endogenous Growth Hormone?

Endogenous Growth Hormone (GH) is the somatotropic polypeptide hormone naturally synthesized and secreted by the somatotroph cells situated in the anterior lobe of the pituitary gland. This vital hormone, also known as somatotropin, is essential for stimulating somatic growth during childhood and adolescence. In adulthood, it continues to regulate body composition, cellular repair, metabolism, and overall endocrine function.

What is the Origin of Endogenous Growth Hormone?

'Endogenous' derives from the Greek endon meaning "within" and genes meaning "producing," indicating an origin inside the organism. 'Growth Hormone' explicitly names its primary physiological function. This term distinguishes the naturally produced hormone from any administered exogenous therapeutic compounds.

What is the Mechanism of Endogenous Growth Hormone?

Growth Hormone secretion is controlled by the hypothalamic hormones Growth Hormone-Releasing Hormone (GHRH) and somatostatin. Once released, GH exerts its effects both directly on target tissues and indirectly by stimulating the liver and other tissues to produce Insulin-like Growth Factor 1 (IGF-1). This GH-IGF-1 axis is a powerful endocrine cascade that promotes protein synthesis, lipolysis, and glucose homeostasis, all of which are critical for tissue maintenance and metabolic health.

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