What is the Origin of Endogenous Growth Hormone Secretion?

The term is rooted in classical endocrinology, specifically the study of the pituitary gland and its key regulatory hormones. Endogenous is derived from the Greek endon (within) and genos (producing), emphasizing the body's self-generated nature of the hormone. The science of GH secretion is intimately linked to the understanding of the growth-promoting and metabolic effects of this peptide.

What is the Mechanism of Endogenous Growth Hormone Secretion?

GH secretion is tightly regulated by the hypothalamic-pituitary axis, primarily through the opposing actions of Growth Hormone-Releasing Hormone (GHRH), which stimulates release, and somatostatin (SRIF), which inhibits it. The release pattern is highly pulsatile, with the largest and most significant pulses typically occurring during the deepest stages of sleep. Once secreted, GH acts directly on tissues and indirectly by stimulating the liver to produce Insulin-like Growth Factor 1 (IGF-1), which mediates many of its anabolic effects.

Endogenous Growth Hormone Secretion

Meaning

Endogenous Growth Hormone Secretion refers to the natural, pulsatile release of Somatotropin, or Growth Hormone (GH), synthesized and secreted by the somatotroph cells within the anterior pituitary gland. This vital anabolic hormone is essential throughout the lifespan, regulating body composition, bone density, muscle mass, and lipid metabolism. Clinically, assessing and supporting the body’s endogenous (internally produced) GH secretion is preferred over external administration, as it respects the natural physiological feedback loops and minimizes the risk of axis suppression.