What is the Origin of Endogenous Growth Factor Signaling?

The term is a combination of 'Endogenous', meaning originating within an organism, and 'Growth Factor Signaling', a foundational concept in cellular and molecular biology. The field gained prominence with the isolation and characterization of nerve growth factor, establishing the importance of these molecules in development and repair.

What is the Mechanism of Endogenous Growth Factor Signaling?

Growth factors initiate their action by binding to specific, high-affinity transmembrane receptors, which typically possess intrinsic tyrosine kinase activity. This binding event triggers a cascade of intracellular phosphorylation and molecular relay events, notably involving the Ras/MAPK and PI3K/Akt pathways. This molecular signaling ultimately leads to changes in gene transcription, promoting cell growth, division, and survival, a process that is itself finely tuned by systemic endocrine signals.

Endogenous Growth Factor Signaling ∞ Area

Endogenous Growth Factor Signaling

Meaning

The complex, internally regulated system of communication within the body mediated by naturally produced polypeptides that govern essential cellular processes. These processes include proliferation, differentiation, migration, and cell survival. This signaling is critical for maintaining tissue homeostasis, orchestrating wound healing, and supporting ongoing neuroplasticity and neuronal health.