Skip to main content

Endogenous GH Pulsatility

Meaning

Endogenous GH pulsatility refers to the natural, intermittent, and rhythmic release of Growth Hormone (mathrmGH) from the anterior pituitary gland, a secretion pattern that is inherently necessary for the hormone’s full biological efficacy. This physiological phenomenon is characterized by distinct, high-amplitude bursts interspersed with periods of low or undetectable mathrmGH secretion, rather than a continuous, steady release. The specific frequency, amplitude, and timing of these pulses, particularly the large pulse during deep sleep, are crucial for regulating somatic growth, metabolism, and body composition throughout the lifespan. Clinical assessment of this pulsatility is essential for diagnosing growth hormone deficiency.