What is the Origin of Endogenous GH?

The term is derived from Greek: endon (within) and genos (producing), signifying that the substance is produced internally. The acronym GH stands for Growth Hormone, named for its primary and most historically recognized function of promoting somatic growth. The distinction with "exogenous" forms became necessary with the advent of therapeutic hormone replacement.

What is the Mechanism of Endogenous GH?

The release of endogenous GH is primarily controlled by two hypothalamic hormones: Growth Hormone-Releasing Hormone (GHRH), which stimulates its secretion, and Somatostatin, which inhibits it. Once secreted, GH exerts its effects directly on target tissues and indirectly by stimulating the liver to produce Insulin-like Growth Factor 1 (IGF-1). This GH-IGF-1 axis then mediates most of the anabolic and metabolic actions, including protein synthesis and lipolysis.

Endogenous GH

Meaning

Endogenous GH, or Endogenous Growth Hormone, refers specifically to the somatotropin peptide hormone naturally synthesized and secreted by the somatotroph cells within the anterior pituitary gland of the human body. This crucial hormone is distinct from any externally administered or synthetic forms. Its pulsatile secretion profile throughout the day and night is vital for regulating linear growth in childhood, maintaining bone density, influencing body composition, and supporting metabolic functions in adulthood. Clinical evaluation of endogenous GH status is essential for diagnosing growth hormone deficiency or excess.

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Endogenous GH

Meaning

Origin

Mechanism

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