What is the Origin of Endogenous Detoxification?

The term combines 'endogenous,' meaning originating from within the organism, and 'detoxification,' referring to the removal of toxic substances. This physiological concept is central to hepatology and nutritional biochemistry, recognizing the liver's role as the body's primary chemical processing plant. Clinical support for this process is essential for managing overall metabolic load and promoting hormonal health.

What is the Mechanism of Endogenous Detoxification?

Detoxification occurs in two main phases within liver cells: Phase I, involving cytochrome P450 enzymes that oxidize, reduce, or hydrolyze toxins, and Phase II, where these modified compounds are conjugated with molecules like glutathione or glucuronic acid. Steroid hormones, such as estrogens and androgens, are metabolized via similar pathways, ensuring their timely clearance and preventing their accumulation, which could disrupt the endocrine system.

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Endogenous Detoxification

Meaning

Endogenous detoxification refers to the body’s intrinsic, biochemically-driven processes for neutralizing and eliminating both internally generated metabolic byproducts and exogenous toxins absorbed from the environment. This vital function is primarily carried out by the liver and kidneys, utilizing a complex series of enzymatic reactions to convert fat-soluble toxins into water-soluble compounds for excretion. Maintaining efficient detoxification is crucial for hormonal balance, as it includes the metabolism of spent hormones.