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Endogenous Clock Genes

Meaning

Endogenous Clock Genes are a specialized group of transcription factors and regulatory proteins that form the molecular machinery responsible for generating and maintaining the intrinsic 24-hour circadian rhythm within nearly every cell of the human body. These genes, including core components like Period (Per), Cryptochrome (Cry), BMAL1, and CLOCK, drive the rhythmic expression of thousands of downstream genes. They are fundamental regulators of metabolic processes, cellular repair, and the cyclic release of hormones. Their proper function is non-negotiable for chronobiological health.