What is the Origin of Endogenous Chemistry?

The term is constructed from the Greek prefix 'endon,' meaning within, and 'genesis,' meaning creation, emphasizing that these processes are internally generated rather than externally administered. It defines the intrinsic biochemical operations of the human body.

What is the Mechanism of Endogenous Chemistry?

This chemistry operates through complex feedback loops, such as those governing the hypothalamic-pituitary axis, where the concentration of circulating hormones directly influences the activity of upstream regulatory glands. For instance, rising cortisol levels inhibit CRH and ACTH release, a negative feedback mechanism designed to tightly control the duration and magnitude of the systemic stress response. This self-regulation maintains hormonal homeostasis.

Endogenous Chemistry

Meaning

Endogenous chemistry describes the totality of chemical reactions and molecular signaling originating entirely within the living organism, forming the basis of internal regulation. This critically includes the synthesis, release, transport, and degradation of the body’s native signaling molecules, most notably the vast array of peptide and steroid hormones. Maintaining this internal chemical milieu is synonymous with physiological health.