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Endogenous Androgen Signaling

Meaning

Endogenous Androgen Signaling describes the entire biological process initiated by androgens, such as testosterone and dihydrotestosterone (DHT), which are naturally synthesized within the body, acting upon their specific receptors in target tissues. This signaling cascade is crucial for maintaining male and female secondary sexual characteristics, bone density, muscle mass, libido, and cognitive vitality. The robustness of this signaling is a key biomarker for overall metabolic and hormonal health, and its decline with age contributes to sarcopenia and reduced quality of life. Optimal signaling relies on adequate hormone synthesis and functional receptor expression.