What is the Origin of Endogenous Androgen Production?

The term is a combination of the Greek prefix endo- meaning within, and andros meaning man, denoting a hormone that generates male characteristics. The process's origin is the complex, multi-step steroidogenesis pathway that begins with cholesterol within the mitochondria of steroidogenic cells. This foundational biological process has been conserved across mammalian evolution to regulate reproductive and somatic development.

What is the Mechanism of Endogenous Androgen Production?

The production is tightly regulated by the Hypothalamic-Pituitary-Gonadal (HPG) axis. Luteinizing Hormone (LH), released by the pituitary, stimulates Leydig cells in the testes to convert cholesterol into testosterone. This testosterone, in turn, acts on target cells or is converted into the more potent dihydrotestosterone (DHT) by the 5-alpha reductase enzyme. A complex negative feedback loop involving testosterone and inhibin ensures precise control over the rate of this production, maintaining hormonal homeostasis.

Endogenous Androgen Production

Meaning

Endogenous Androgen Production is the natural, internal synthesis of androgenic steroid hormones, such as testosterone and dehydroepiandrosterone (DHEA), by the human body. These crucial sex steroids are produced primarily in the testes and ovaries, with a significant contribution from the adrenal glands in both sexes. This process is fundamental for the development of male characteristics, the maintenance of muscle and bone mass, and the regulation of libido in both men and women.