Skip to main content

Endocrine System Stress Response

Meaning

The Endocrine System Stress Response is the coordinated physiological cascade initiated by the neuro-endocrine system to maintain homeostasis when faced with a perceived or actual threat, known as a stressor. This adaptive response involves the rapid secretion of hormones that mobilize energy reserves and modulate vital bodily functions to prepare for “fight or flight.” Sustained or excessive activation of this system, however, contributes to allostatic load and can lead to chronic endocrine dysregulation. Clinically managing this response is central to preventing long-term metabolic and immune compromise.